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I am taking warfarin (brand name Coumadin) for a blood clot in my leg (DVT). Will the pain in my leg ever go away?

Henry I. Bussey, Pharm.D., FCCP, FAHA
February, 2006

Typically, there may be a fair amount of pain and swelling when a deep vein thrombosis (DVT) develops. This pain is partly due to swelling in the vein in the leg with the blood clot. With appropriate therapy, however, the inflammation - and therefore the pain - usually resolves significantly within a few days. If severe pain remains, then you may need to be evaluated for another cause of the pain and/or to see whether the therapy for the DVT is adequate to "turn off" the clotting process.

Additionally, there also is concern that the pain and swelling can become an ongoing problem called "post-thrombotic syndrome." Post-thrombotic syndrome is sometimes referred to as chronic venous insufficiency (CVI) or as post-phlebitic syndrome. Pain in the leg from post-thrombotic syndrome may remain even after a blood clot has fully dissolved.

So, what exactly is post-thrombotic syndrome?

Inside your veins, there are little valves that help support the weight of the blood in the veins and help blood flow back to the heart. When a DVT occurs, the valves often become inflamed and may not function normally after that. If these valves are damaged by the swelling from the DVT, then circulation in the affected leg may be reduced. This reduced circulation can lead to pain and swelling in the leg. In some cases, a patient may notice changes in skin color and texture or even sores or skin ulcers. This pain and swelling is called post-thrombotic syndrome. In addition to causing pain and swelling in the leg, post thrombotic syndrome causes reduced circulation that is thought to increase the risk of additional blood clots.

So, what can I do to reduce this pain and swelling in my leg?

Elastic graduated compression stockings have been shown to reduce the risk of developing post-thrombotic syndrome and the risk of having another DVT. Consequently, we usually prescribe such stockings for our patients with DVT. Applying such stockings may be difficult, however, if the leg is significantly swollen and the pain severe. You can learn more about graduated compression stockings including information on where to get them and how to put them on by clicking here to read our FAQ on graduated compressions stockings.

Other things you can do to help improve circulation and reduce the pain and swelling of post-thrombotic syndrome are:

  • Exercise
  • Elevate your feet when sitting
  • Avoid tight-fitting clothing
  • Do not cross your legs at the knee when seated

Note: You should never begin an exercise program without first discussing it with your healthcare provider.

Want does post-thrombotic syndrome look like?

If you would like more information on post-thrombotic syndrome and/or would like to see a demonstration of how to apply graduated compression stockings, you may review a video on this topic at Please note that this video was made for healthcare providers, so there is a considerable amount of medical language used. The video is narrated by Joseph A. Caprini, MD, MS, FACS, RVT and is part of his website

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Thursday, July 18, 2024