Tinzaparin (Innohep) use associated with higher mortality rate in elderly with renal insufficiency

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Pick a Topic: Home New Postings Patient Postings Clinician Postings Join Our Email List Useful Web Links CE Opportunities Training Programs Guidelines DVT & PE Stories Editorial Board Financial Support About ClotCare DVT Coalition Contact Us Find info on a: Specific Medicine or Treatment Type of Medicine or Treatment Condition or Medical Procedure Lab Test Procedure Management Issue ClotCare complies with the HONcode standard for trustworthy health information: verify here. ClotCare is a member organization of the Coalition to Prevent Deep Vein Thrombosis. Click here to learn more about the Coalition to Prevent Deep Vein Thrombosis and DVT Awareness Month, which is held each March.	Tinzaparin (Innohep) use associated with higher mortality rate in elderly with renal insufficiency Henry I. Bussey, Pharm.D., FCCP, FAHA December, 2008 On December 2, 2008, the FDA at www.fda.gov/medwatch/safety/2008/safety08.htm#Innohep posted a warning regarding the use of tinzaparin (Innohep) in elderly patients with renal insufficiency and cite a study which was terminated early because of an increased mortality rate in such patients compared to those receiving unfractionated heparin. Little information is available at this time as to the cause(s) of death, whether there may have been a problem with the source of tinzaparin, and/or whether or not the dose of tinzaparin was adjusted for renal function or whether potential accumulation of the drug was evaluated. More data should be forthcoming as the FDA-ordered review is completed and the data published.	Have questions? Ask ClotCare. Send questions by email to webmaster@clotcare.org. ClotCare is a 501(c)(3) non-profit organization generously supported by your tax-deductible donations and grants from our industry supporters. New Postings: Click here to view full list of new postings
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